Pradaxa – Management of Major Bleeding
Major and life-threatening bleeding is expected to occur in some patients treated with Pradaxa® (=Dabigatran). The question will then urgently arise how to best treat such catastrophic bleeding. As...
View ArticleBeing on Blood Thinners: How Do I Know I am Bleeding?
Emily Hawes, UNC School of Pharmacy, writes… Patients on blood thinners are at increased risk for bleeding. This can be easy to recognize external bleeding (bruising, bleeding from a cut, nosebleeds,...
View ArticleMinor Cuts and Bleeding on Blood Thinners
A patient on an anticoagulant (blood thinner) may bleed more easily and it may be more difficult to stop bleeding. To help stop bleeding with minor cuts or nosebleeds, several over-the-counter...
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Red Eye – Subconjunctival Bleed on Blood Thinners
Stephan Moll, MD, writes… A subconjunctival bleed (hemorrhage) is a bleed underneath the transparent conjunctiva , and in front of the white (sclera) of the eye ball (see image). The conjunctiva...
View ArticleKcentra – FDA Approval of New Drug for Reversal of Warfarin
Stephan Moll, MD writes… A new drug for the urgent reversal of warfarin was approved by the FDA today, April 29th, 2013, (announcement by the FDA is here), called Kcentra. The drug is derived from...
View ArticleMajor Bleeding on Pradaxa (Dabigatran) – Interesting Publication
Stephan Moll, MD writes… Interesting publication this week in Circulation: “Management and outcomes of major bleeding during treatment with dabigatran or warfarin” (Majeed A et al; published online...
View ArticleNew Publication: Increased Bleeding Risk When Taking Blood Thinners Together...
Bruce L Davidson, MD, writes… Our study published in JAMA Internal Medicine [reference below] used patient information (with no identifying information, so confidentiality was preserved) from the two...
View ArticleMajor Bleeding on Blood Thinners: Practical Guideline
Stephan Moll, MD writes… Major bleeds on blood thinners (such as Coumadin, Jantoven, Eliquis, Pradaxa, Xarelto) and anti-platelet drugs (like aspirin, Plavix, Brilinta, Effient, etc.) occur every so...
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Major Bleeding on the New Oral Blood Thinners: Update on Reversal Drugs
Stephan Moll, MD writes (on Nov 7th, 2014)… A publication this week in the New England Journal of Medicine reports on a new reversal agent (PER977 = Aripazine = ciraparantag) that may be effective...
View ArticleAntidote for Pradaxa (Dabigatran): FDA Approval By End of 2015?
Stephan Moll, MD writes: A drug in development (Idarucizumab) that reverses the blood thinner Pradaxa® (Dabigatran) is on a very promising path to get FDA approval in the next few months and be...
View ArticleContraceptive Use While on Blood Thinners is Safe
Stephan Moll, MD writes… Interesting and relevant publication this week [reference 1]. It is well known that estrogen–containing birth control methods (pills, vaginal rings, patches, injectables)...
View ArticleIncreased Menstrual Bleeds on Xarelto?
Stephan Moll, MD writes… Interesting observations published in the last 2 weeks: Heavy menstrual bleeding appears to occur more commonly with Xarelto® than with warfarin [ref 1] and may be also more...
View ArticleNO FDA Approval Yet for Antidote for Xarelto, Eliquis and Savaysa
Stephan Moll, MD writes… The FDA did NOT approve Andexanet (brand names: AndexXa™ in the US, IndexXa™ in Europe) in a decision on August 18th, 2016. Andexanet is the drug in clinical trials as an...
View ArticleMajor Bleeding on Dabigatran (Pradaxa) – Interesting Publication
Stephan Moll, MD writes… Interesting publication this week in Circulation: “Management and outcomes of major bleeding during treatment with dabigatran or warfarin” (Majeed A et al; published online...
View ArticleLMWH and Epidural Catheters – FDA Recommendations
Stephan Moll, MD writes… The FDA published today a drug safety recommendation to decrease bleeding and paralysis risk for patients receiving epidural catheters and being treated with LMWH (detailed...
View ArticleAntidotes for the New Oral Anticoagulants: Update
Stephan Moll, MD writes (on Nov 7th, 2014)… A N Engl J Med publication this week [ref 1] reports on a new reversal agent (PER977 = Aripazine = ciraparantag) that may be effective against a number of...
View ArticleReversal Agent for Pradaxa: Important NEJM Publication Today
Stephan Moll, MD writes… A publication in the New England Journal of Medicine today reports on the use of the Pradaxa® (Dabigatran) antidote Idarucizumab in patients on Pradaxa® who present with major...
View ArticleBleeding on Antithrombotics: Reversal Protocol 2016
Stephan Moll, MD writes… Our medical center (University of North Carolina Hospitals, Chapel Hill) has put together a comprehensive “Emergent Anticoagulation Reversal Guideline” for our local use,...
View ArticleContraceptive Use While on Anticoagulants is Safe
Stephan Moll, MD writes… Interesting and clinically relevant publication this week [ref 1]. It is well known that estrogens and certain progestin preparations increase the risk for venous...
View ArticleHeavier Menstrual Bleeding on Xarelto?
Stephan Moll, MD writes… Interesting and noteworthy observations published in the last 2 weeks: Heavy menstrual bleeding appears to occur more commonly with Xarelto® than with warfarin [ref 1] and may...
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